Our pharmacist answers the latest question regarding whether or not your deserve to take Benadryl (diphenhydramine) with Nyquil.

You are watching: Can you mix benadryl and nyquil



At a glance

NyQuil has doxylamine, a sedating first-generation antihistamine. Benadryl contains diphenhydramine, likewise a sedating first-generation antihistamine. Use of both together rises the hazard of side results such as oversedation, dry mouth, dry eyes and constipation.



In many cases, it is not recommfinished to take Benadryl (diphenhydramine) and also Nyquil together because they both contain sedating antihistamines.<1>

The sedating antihistamine in NyQuil is doxylamine, which is very very closely related to diphenhydramine (the energetic ingredient in Benadryl). In reality, they are in the same class of medication, sedating first-generation antihistamines.

Taking two first-generation antihistamines together is taken into consideration "duplicate therapy" and increases the risk of side results occurring.

What Is Benadryl?

Benadryl is classified as a first generation antihistamine. The duration of action of the drug is generally 4-6 hours per dose (25 mg to 50 mg).<2>

First generation antihistamines are recognized for their sedative effects and also CNS (main nervous system) depressant impacts. Many kind of people cannot toleprice the sedative effects of Benadryl (diphenhydramine) throughout the day and also, therefore, only take it at bedtime to combat insomnia.

What Is NyQuil?

Nyquil is a mix cold/cough product that has the drug doxylamine, in addition to a pain/fever reducer (acetaminophen) and also a cough suppressant (dextromethorphan).

Doxylamine is a sedating first-generation antihistamine and is in the very same course of medication as Benadryl (diphenhydramine).<3>

Interactivity Explained

As declared above, both doxylamine and also Benadryl (diphenhydramine) job-related the exact same way and also are actually in the very same course of medication.

They occupational by blocking the histamine-1 receptor in the body, which prevents histamine from binding to it and also developing the symptoms we are all extremely familiar with (e.g. runny nose, watery eyes, and so on..).

Due to the fact that both drugs occupational the exact same means, making use of both at the exact same time is not recommended.

Combined usage mainly won"t provide any more benefit than taking either alone. Additionally, taking them together not only rises the hazard of excessive sedation, it substantially boosts the danger of extra adverse results such as:<4>

Dry mouthDry eyesConstipationConstricted airways

Very high doses of sedating antihistamines have also been associated via excitation, agitation, and restlessness.<5>

When Is Use Together Okay?

Having sassist that, tright here can be a case to take the combicountry together.

Benadryl (diphenhydramine) has actually sensibly strong proof for usage in stemming allergic reactions.

Studies present that Benadryl (diphenhydramine) deserve to efficiently minimize itching and swelling from reactions to points prefer bee stings and poison ivy.

See more: Cuanto Dinero Se Puede Llevar En Avion, ¿Trae Mucho Dinero En Efectivo A Ee


If you have actually currently taken a dose of Nyquil and are having actually an allergic reaction to somepoint, taking a dose of Benadryl (diphenhydramine) might assist without a vast boosted risk in intolerable side impacts.