Diethyl ether is most likely the a lot of commonly employed solvent for the extraction of clomiphene <14,16>, For instance, clomiphene was extracted from 3 mL of plasma in 1 mL boprice buffer, pH 9, with an extractivity performance of 70% at 30 ng/mL <14>.

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From: Analytical Profiles of Drug Substances and also Excipients, 1998

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F. Monticelli, in Encyclopedia of Toxicology (Third Edition), 2014


Diethyl ether (CAS 60-29-7) is a component of starting fluids and is provided as a solvent in the manufacture of man-made dyes and plastics. Since of its attributes diethyl ether was widely used in many nations as an anesthetic agent, but was then replaced by other substances in the 1960s. The major path of expocertain is inhalation. The device and website of activity of diethyl ether are still not recognized in detail. The effects of diethyl ether on the main nervous system are greatly attributed to interactions through neuronal membranes and ion channels.

Piet de Coning, John Swinley, in A Practical Guide to Gas Analysis by Gas Chromatography, 2019

11.9.2 Diethyl ether

Diethyl ether has a high volatility and also low flash suggest and has actually been used with petroleum distillates as a starting liquid for diesel engines. It was widely offered as an anaesthetic agent yet because of its flammcapability and also post-anaesthetic side effects has been replaced with halogenated ethers. It is, but, still provided as a recreational drug. The major application location is as a solvent in commercial and also laboratory applications.

Diethyl ether can be separated from a lot of widespread solvents making use of non-polar or moderately polar WCOT columns. In facility matrices such as gaseous hydrocarbons it is arguably best separated from many of the matrix components utilizing the extremely polar PLOT columns such as the GS-OxyPLOT column from Agilent. These columns will certainly elute all the non-oxygenated hydrocarbons as much as octane initially complied with by the oxygenated compounds starting via dimethyl- and also diethyl ether.

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In an application as in Fig. 11.14, 2 columns are associated in series utilizing a multiport valve that permits back-flushing of the pre-column to vent or to another column and detector. The sample is introduced right into the non-polar pre-column via which the oxygenated compounds, being not well retained, pass quickly via onto the PLOT column together with the volatile hydrocarbons. On the PLOT column the hydrocarbons are not well kept and also pass with to the detector first without considerable additionally separation. The oxygenated compounds interact a lot more through the PLOT column and are separated and also elute after the hydrocarbons <19>.